Deriving PLA from MaxCal

The principle of least action (PLA), or more accurately, the principle of stationary action, is one first principle in physics. PLA offers the deepest explanatory power of our external reality. In this blog, I shall summarise a beautiful paper “Principle of maximum caliber and quantum physics” [1]. I shall omit the part of quantum physicsContinue reading “Deriving PLA from MaxCal”

Inference of Gene Regulatory Networks using MaxEnt

In my first blog, I introduced the principle of maximum entropy (MaxEnt). Here I shall use an example of inferring Gene Regulatory Networks as proposed [1] to see how to apply MaxEnt. Recalled that with MaxEnt, any problem of interest is a problem of inferring the least biased or the most uncertain probability distributions fromContinue reading “Inference of Gene Regulatory Networks using MaxEnt”